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KMID : 0351619680090010097
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Kyungpook Medical Journal
1968 Volume.9 No. 1 p.97 ~ p.107
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Ethylenediamineteraacetic Acid Disodium(EDTA) on Urinary Outflow and Electrolytes in Dogs
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Abstract
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Under the infusion of physiological saline solution containing 0.2% inulin (Inulin-Saline) into the femoral vein, EDTA, a chelating agent, and Lasix (Furosemide), a saluretic agent, were added to the solution filtration rate (GFR) and changes on urinary outflow and electrolytes observed.
Experimental animals were divided into five groups : control; infused with solution of Inulin-Saline-EDTA; of Inulin-Saline+EDTA; of Inulin-Saline+Lasix; and of Inulill-Saline-EDTA+ Lasix.
The results were as follows:
1. There were no significant changes in urinary outflow and GFR between the groups of Inulin-Saline and Inulin-Saline+ EDTA. (In Inulin-Saline+EDTA groups, however, urinary sodium, potassium and calcium were considerably increased but chloride was not.
2. The rate of increase in the urinary sodium and potassum were lowered in Inulin-Saline+EDTA group, while calcium was more prominant compared with Inulin-Saline+Lasix group.
3. When EDTA was combined with Lasix, urinary excretion of potassium, calcium were additive and sodium was potentiative.
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